The familial incidence of multiple neurofibromatosis, or von Recklinghausen's disease, has long been noted, and most authors today accept the fact that there is a hereditary transmission of the disease. Harbitz,1 in a review of multiple neurofibromatosis, reported a case of elephantiasis of the left lower extremity and stated that a similar condition had existed in four previous generations. He termed the disease "elephantiasis neuromatosa congenita." Castellino2 stated, "The disease assumes a familial character and may be transmitted to the first, second or third generations." Preiser and Davenport,3 in a review of cases in which there were two or more offspring of an affected parent, found that of 115 offspring 50 were affected and concluded, as did Cockayne,4 that the defect is a simple dominant.
The following is a report of a case in which von Recklinghausen's disease can be traced through five generations. The patient,
FRANK L. VON RECKLINGHAUSEN'S DISEASE: Traced Through Five Generations. Arch Derm Syphilol. 1947;55(1):109–110. doi:10.1001/archderm.1947.01520010113012
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