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February 1947

EOSINOPHILIC GRANULOMA: Theoretic and Practical Considerations Based on the Study of a Case

Author Affiliations


From the New York Hospital and the Department of Medicine (Dermatology), Cornell University Medical College.

Arch Derm Syphilol. 1947;55(2):176-193. doi:10.1001/archderm.1947.01520020025002

A PATIENT with bizarre, recurrent, eosinophilic tumefactions of the skin has been under observation for the past three and one-half years. The clinical findings, in comparison to those noted in previous reports, are unique inasmuch as the individual lesions have been of relatively short duration with a tendency to spontaneous disappearance, are acutely inflammatory in nature and are completely insensitive to irradiation with roentgen rays.

As a background for discussion of this case, the pertinent literature will first be summarized. Following the presentation of the case, an attempt will be made to link up the various eosinophilic tumefactions into a logical pattern and to clarify the relationship between these lesions and eosinophilia in general.

SUMMARY OF ANALOGOUS CASES  The first case of cutaneous eosinophilic granuloma to be reported was that of Freund1 in 1930. His patient had active pulmonary tuberculosis. For six years there were present livid red, semicircular

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