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Article
February 1947

TREATMENT OF VARIOUS TYPES OF CUTANEOUS TUBERCULOSIS WITH PROMIZOLE AND STREPTOMYCIN: A Preliminary Report

Author Affiliations

ROCHESTER, MINN.

Dr. O'Leary and Dr. Ceder are from the Section on Dermatology and Syphilology, Mayo Clinic; Dr. Hinshaw is from the Division of Medicine, Mayo Clinic, and Dr. Feldman is from the Division of Experimental Medicine, Mayo Foundation.

Arch Derm Syphilol. 1947;55(2):222-232. doi:10.1001/archderm.1947.01520020071005
Abstract

This preliminary report on treatment of certain types of cutaneous tuberculosis and tuberculids is part of a study of various agents in the treatment of tuberculosis that was started several years ago by two of us (Feldman and Hinshaw).1 This report deals with the clinical application to cutaneous tuberculosis of promizole2 and streptomycin,3 which were found to be the least toxic and have demonstrated the greatest therapeutic effect of any of the substances which were used in treatment of tuberculous guinea pigs.

Since Ehrlich developed the satisfactory arsenical for treatment of syphilis, a constant search has been made for some similarly effective agent for the treatment of tuberculosis. Although results with use of metallic substances have been unsuccessful, with the advent of the sulfonamide compounds, the sulfones and, shortly afterward, the antibiotic agents, investigation in this field was stimulated again.

Rich and Follis,4 in 1938, were

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