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Article
February 1947

DYSKERATOSIS CONGENITA WITH PIGMENTATION, DYSTROPHIA UNGUIUM AND LEUKOPLAKIA ORIS: Patient with Evidence Suggestive of Addison's Disease

Author Affiliations

NEW YORK

From the Skin and Cancer Unit of the New York Post-Graduate Medical School and Hospital, Columbia University College of Physicians and Surgeons, service of Dr. Fred Wise.

Arch Derm Syphilol. 1947;55(2):242-250. doi:10.1001/archderm.1947.01520020097007
Abstract

IN A PREVIOUS article1 2 brothers were described who had the main features of the syndrome named by Cole and associates. Of considerable importance was the pronounced improvement in the leukokeratotic patches of the mucous membrane of the mouth and tongue of the older brother, J. W., following medication for several weeks with testosterone propionate. In this paper I am reporting the findings in the patient J. W. of the various tests and examinations and the results of treatments with adrenocortical hormones, all of which are suggestive of the presence of associated Addison's disease. This is a part of the investigative work now being carried on by Dr. Fred Wise and myself, with the view of collecting data on the presence of pathologic changes in the adrenal glands in various chronic and resistant dermatologic diseases, as has already been reported by Garb and Wise in a case of mycosis

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