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March 1947


Arch Derm Syphilol. 1947;55(3):405-416. doi:10.1001/archderm.1947.01520030098017

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Xanthoma Disseminatum (also Tuberosum et Planum). Presented by Dr. John G. Downing, Boston.  F. C., a 44 year old white man of Irish-American descent, was presented from the Massachusetts Memorial Hospitals. Five years ago the patient noted the appearance of yellowish lesions on the palms and a yellowish tint in his eyes. The lesions gradually became generalized. Some loss of weight and fatigue were also apparent. Three years ago an examination revealed an enlarged liver. For the past year the yellowing of the skin has been progressive. The urine has been dark, and from five to six light brown stools have been passed daily. He has been increasingly fatigued.At this time the patient presents deep jaundice of the skin, mucous membranes and scleras. Numerous nevi aranei are seen on the upper part of the trunk and the neck. The palms, flexor creases of the fingers, cubital fossae, axillary folds,

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