PRIMARY and secondary pyogenic infections of the skin make up a large proportion of dermatologic conditions in patients in the military services. In the hot and more tropical areas this group assumes increasing importance and comprises a constant problem.
The amazing effectiveness of penicillin on some of the pyogenic organisms would warrant a trial in purulent infections of the skin in which the process could be subjected directly to penicillin. Penicillin has been incorporated into water-miscible bases in varying concentrations. Cohen and Pfaff1 used 1,666 units of penicillin per gram, with effectiveness, in impetigo contagiosa, carbuncles, herpes zoster with secondary impetigo and sycosis barbae. Johnson2 reported excellent results in the same type of cases using a concentration of 166 units per gram of ointment base.
Vesicular and intertriginous fungous infections of the feet having secondary invasion by staphylococci and streptococci constitute a large group of conditions in patients
HOFFMAN BJ. TOPICAL USE OF PENICILLIN IN TREATMENT OF PYODERMA. Arch Derm Syphilol. 1947;55(5):630–632. doi:10.1001/archderm.1947.01520050032003
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