SOON after the demonstration by Mahoney, Arnold and Harris1 that penicillin was effective against Treponema pallidum, a number of investigators2 reported the early effect of penicillin treatment as characterized by the disappearance of organisms from surface lesions, the healing of lesions. and the reversal of serologic reactions.
It is the purpose of this paper to describe the results of treatment of 34 patients on an assigned schedule of treatment of 600,000 units.3 A follow-up of 100 per cent of the cases for at least a year has afforded an unusual opportunity to observe the results of the time-dosage schedule employed.
METHOD OF STUDY
Between April 1, 1944 and Nov. 1, 1944, there were 34 patients with early acquired syphilis treated with penicillin on a schedule of 600,000 units given over a period of four days. There were 13 men and 21 women, 4 of whom were white
SMITH DC, KAUFMAN WH, SHAFER JC. TREATMENT OF EARLY ACQUIRED SYPHILIS WITH 600,000 UNITS OF SODIUM PENICILLIN. Arch Derm Syphilol. 1947;55(5):644–649. doi:https://doi.org/10.1001/archderm.1947.01520050046006
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