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May 1947

PEMPHIGUS FOLIACEUS: A Patient Treated with an Unusual Amount of Acetarsone

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Arch Derm Syphilol. 1947;55(5):691-692. doi:10.1001/archderm.1947.01520050093013

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E. W., a white woman 52 years of age, when first seen in September 1942 had a vesicobullous eruption involving almost the entire body, including the mouth, vagina and rectum. She had lost 25 pounds (11.3 Kg.) in weight and was confined to her bed. The eruption had been of a year's standing and had received a variety of haphazard treatment. In the early phase of the eruption a dermatologist had made a diagnosis of erythema multiforme, but treatment for this had not been systematic. When seen by me it was a typical case of advanced pemphigus vulgaris, with possibly a tendency to the foliaceus type. In September 1942 she was given acetarsone, 0.25 Gm., according to the regimen advocated by Oppenheim. Response was prompt. In order to try the effect of suramin sodium, the administration of acetarsone was interrupted. Suramin sodium was, however, poorly tolerated, so in December 1942

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