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May 1947


Arch Derm Syphilol. 1947;55(5):705-710. doi:10.1001/archderm.1947.01520050107018

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A Case for Diagnosis (Scleredema Adultorum? Scleroderma?). Presented by Dr. E. W. Abramowitz.  Mrs. E. L., a woman aged 57, born in Germany, first noted stiffness of the shoulders in 1941. This has gradually spread so that now the neck, chest, arms and thighs present a leathery hardness. The hands and feet are not affected. The disturbance appeared suddenly, with no previous illness or operation except a hysterectomy in 1925.Since 1941 the patient has received fever therapy, injections of typhoid vaccine and roentgen therapy, without relief. She has had a thorough physical examination at the Mayo Clinic and at the New York Post-Graduate Medical School and Hospital, where electrocardiographic, encephalographic and basal metabolic tests revealed a normal condition.The patient has been under my observation since June 22, 1945. She is receiving neostigmine, 15 mg. two or three times daily, with baking and massage. The skin has at times

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