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June 1947

PENICILLIN IN THE TREATMENT OF EXPERIMENTAL SYPHILIS OF RABBITS: I. The Therapeutic Activity of Penicillin in Single and Multiple Doses in Isotonic Solution of Sodium Chloride and Peanut Oil-Beeswax by Intramuscular Injection

Author Affiliations

Professor of Medicine, Temple University School of Medicine; Director of the Research Institute of Cutaneous Medicine; PHILADELPHIA

From the Research Institute of Cutaneous Medicine.

Arch Derm Syphilol. 1947;55(6):741-748. doi:10.1001/archderm.1947.01520060003001

STUDIES bearing on penicillin in the treatment of experimental syphilis of rabbits are of value in relation to the treatment of human syphilis, as has been found true of the organic arsenical and bismuth compounds. Not only are the clinical effects of the compound on acute testicular and cutaneous lesions and on spirochetes in these lesions readily observed by means of dark field examinations, but dosage in relation to complete or biologic cure may be determined with a fair degree of accuracy by means of transfer of lymph nodes.

PRINCIPLES INVOLVED  It is true that the total dosage of penicillin per kilogram of weight required for the biologic cure of acute testicular syphilis of rabbits is much less than that required for the treatment of early syphilis of human beings. However, valuable information may be gained in relation to methods of administration, the relative therapeutic effectiveness of penicillins F, G,

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