ACANTHOSIS nigricans has been a disease of interest to dermatologists and internists since it was first independently described in 1890 by Pollitzer1 and Janovsky.2 Reports of about 400 cases of acanthosis nigricans have appeared to date in the medical literature.3 The conditions in these cases have been divided almost equally into the adult type, occurring in persons after the age of 20 years, which is usually associated with intra-abdominal malignant growth, and the juvenile benign type, occurring in persons under 20 years of age, without evidence of internal malignant growth. According to Curth,3c however, no strict dividing line in age is possible between the so-called malignant and benign forms of acanthosis nigricans, as in some of the cases of the juvenile type either an internal malignant growth has developed while the patient was under 20 years of age or an internal malignant growth has appeared later in
ROBINSON SS, TASKER S. ACANTHOSIS NIGRICANS JUVENILIS ASSOCIATED WITH OBESITYReport of a Case, with Observations on Endocrine Dysfunction in Benign Acanthosis Nigricans. Arch Derm Syphilol. 1947;55(6):749–760. doi:10.1001/archderm.1947.01520060011002
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