THE PRINCIPLES OF LOCAL THERAPY WITH PENICILLIN OINTMENT MIXTURES
THE EFFECTIVE antimicrobial properties of penicillin make its range of application extensive. Early in the investigative history of this antibiotic its topical action was recognized. Since that time, attempts have been make to employ penicillin in the treatment of numerous diseases of the skin. Because of the many factors involved in the topical application of a relatively unstable chemotherapeutic agent, the use of penicillin in ointment form for cutaneous infections has not been a simple matter. Our own experiences with more than 400 cases, however, show that, when properly prepared and rationally employed, penicillin ointment mixtures are of value in dermatologic therapy.With penicillin ointments in their present state of development, certain important factors must be considered in their preparation, storing, dispensing and application to insure maximum therapeutic effectiveness.
Factors to be considered are: (1) stability, (2) dispersion of
GOLDMAN L, SUSKIND RR, FRIEND F. TOPICAL PENICILLIN THERAPY: The Principles of Local Therapy with Penicillin Ointment Mixtures. Arch Derm Syphilol. 1947;55(6):793–800. doi:10.1001/archderm.1947.01520060055006
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.