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June 1947

TOPICAL PENICILLIN THERAPY: The Principles of Local Therapy with Penicillin Ointment Mixtures

Author Affiliations


From the Department of Dermatology and Syphilology of the University of Cincinnati College of Medicine and the Antibiotic Laboratory of the Cincinnati General Hospital, Dr. Raymond Suskind, Director.

Arch Derm Syphilol. 1947;55(6):793-800. doi:10.1001/archderm.1947.01520060055006

THE PRINCIPLES OF LOCAL THERAPY WITH PENICILLIN OINTMENT MIXTURES  THE EFFECTIVE antimicrobial properties of penicillin make its range of application extensive. Early in the investigative history of this antibiotic its topical action was recognized. Since that time, attempts have been make to employ penicillin in the treatment of numerous diseases of the skin. Because of the many factors involved in the topical application of a relatively unstable chemotherapeutic agent, the use of penicillin in ointment form for cutaneous infections has not been a simple matter. Our own experiences with more than 400 cases, however, show that, when properly prepared and rationally employed, penicillin ointment mixtures are of value in dermatologic therapy.With penicillin ointments in their present state of development, certain important factors must be considered in their preparation, storing, dispensing and application to insure maximum therapeutic effectiveness.

1. Preparation.—  Factors to be considered are: (1) stability, (2) dispersion of

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