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Article
June 1947

EOSINOPHILIC GRANULOMA OF BONE WITH CUTANEOUS MANIFESTATIONS: Report of a Case

Author Affiliations

ANN ARBOR, MICH.

Arch Derm Syphilol. 1947;55(6):810-818. doi:10.1001/archderm.1947.01520060072008
Abstract

INTEREST of pathologists and orthopedic surgeons has within recent years been focused on a newly classified group of diseases, comprising Hand-Schüller-Christian disease, a relative newcomer, assigned the eponym Letterer-Siwe disease, and a third, variously known as eosinophilic or destructive granuloma of bone. Occurrence of both cutaneous lesions and visceral involvement as prominent accompaniments of these processes recommends further study and investigation by dermatologist and internist.

Letterer-Siwe disease, so titled because of the original description by Letterer and the subsequent collection and grouping of cases by Siwe1 appears to be the severest, eosinophilic granuloma the mildest and Hand-Schüller-Christian disease the intermediate manifestation of an identical underlying basic disease.2 This classification necessitates withdrawal of Hand-Schüller-Christian disease from its previously held position in the group known as diseases of lipid metabolism, remaining members of which are Gaucher's disease and Niemann-Pick disease. Recent investigations lend weight to the accuracy of this reshuffling.

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