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Article
June 1947

Penicillin in Neurology

Arch Derm Syphilol. 1947;55(6):868. doi:10.1001/archderm.1947.01520060130022

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Abstract

The authors have reviewed the literature relative to the effects of antibiotics on the central nervous system and have presented their own interesting experimental and clinical data. Major attention is given to the toxic effects of penicillin when administered parenterally, when applied directly to nervous tissue or when injected into the lateral ventricles, the cisterna cerebellomedullaris or other subarachnoid space. The therapeutic value of penicillin and other antibiotics in various infectious and noninfectious diseases of the central nervous system has been covered adequately.

Of chief interest to the dermatologist is the section devoted to the treatment of syphilis of the central nervous system. The subject is considered briefly, and it is noteworthy that not one of the twenty references in the bibliography pertain to articles published later than 1945. The tempo of investigation in neurosyphilis has been so rapid that it has outstripped the material published in this book. Reference

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