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July 1947


Arch Derm Syphilol. 1947;56(1):122-128. doi:10.1001/archderm.1947.01520070125016

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Reticuloendotheliosis (Letterer-Siwe Disease). Presented by means of color photographs by Dr. Margaret Jane Addison (by invitation), Boston.  J. W., a white infant aged 8 months, was admitted to Babies and Childrens Hospital. At birth there were diffuse petechiae on the trunk and hands. They underwent remission during treatment with vitamin K. The child ate well, but always cried and was never able to sit up. Later the skin showed crusted lesions, then bullous lesions. The parents noted a contrasting chalky white appearance of the skin.The mother and father were well; the mother had had rheumatic fever in 1939. There were 3 healthy siblings, aged 8, 6 and 3 years.On his admission, on June 20, 1945, petechiae were seen on the trunk, being most numerous on the upper part of the back and the occiput. There were several large bullae on the buttocks and the inner surfaces of the

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