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Article
August 1947

LUPUS ERYTHEMATOSUS TREATED WITH VASODILATORS AND COLLOIDAL GOLD SULFIDE

Author Affiliations

CHICAGO

From the Northwestern University Medical School and the Outpatient Department of Grant Hospital.

Arch Derm Syphilol. 1947;56(2):248-255. doi:10.1001/archderm.1947.01520080108012
Abstract

THIS report deals with the results obtained in the treatment of lupus erythematosus with vasodilators and colloidal gold sulfide. Some interesting observations on the relationship of leukopenia, albuminuria and hypertension to the clinical condition of patients were noted.

Kuehnau1 and Tarentelli2 were among the early investigators to employ vasodilator therapy in lupus erythematosus. They used the amide of nicotinic acid and reported encouraging results. Recently I reported on the theory and practical use of vasodilators in the management of various dermatoses.3 Rapid improvement was noted in erythema multiforme and in actinic eruptions. My conclusions were confirmed by Weisberg and Rosen.4

For many years I have entertained the idea that anoxia of tissue induced by spasm of the blood vessels prevents gold from reaching the unhealed active lesions of lupus erythematosus. This belief was substantiated by the experiments of Beinhauer, Jacob and Beebe,5 who found that

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