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Article
September 1947

VITAMIN A IN DARIER'S DISEASE

Author Affiliations

ESSEX, ENGLAND; LONDON, ENGLAND; CHICAGO

From St. John's Hospital for Diseases of the Skin, London, England.

Arch Derm Syphilol. 1947;56(3):306-316. doi:10.1001/archderm.1947.01520090026003
Abstract

SINCE the first description by Darier1 in 1889 more than three hundred and fifty papers have been published dealing with Darier's disease, a relatively rare condition, the cause of which, in spite of numerous investigations, remains undetermined. New knowledge of vitamin deficiency states brought promise of a fresh attack on the problem. Peck, Chargin and Sobotka (1941),2 having noted the resemblance between the appearance of the skin in naturally occurring vitamin A deficiency and Darier's dyskeratosis, treated a patient with vitamin A and reported improvement. Since then many other patients have been similarly treated, many with benefit. The object of this paper is to describe our studies on the effect of vitamin A in 7 cases of Darier's disease and to compare our results with those of others. Brief notes of our own series of cases are as follows:

REPORT OF PRESENT SERIES OF CASES 

Case 1.—  Mr.

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