[Skip to Navigation]
Article
September 1947

TREATMENT OF CUTANEOUS TUBERCULOSIS WITH LARGE DOSES OF VITAMIN D2

Author Affiliations

MINNEAPOLIS; DES MOINES, IOWA

From the Division of Dermatology of the University of Minnesota, Dr. Henry E. Michelson, Director.

Arch Derm Syphilol. 1947;56(3):317-324. doi:10.1001/archderm.1947.01520090037004
Abstract

DURING the last two years numerous reports have appeared in the European literature concerning the use of vitamin D in the treatment of cutaneous tuberculosis. Investigators in Belgium, France and England independently investigated the oral administration of large doses of vitamin D2.

In the years which followed the announcement by Steenbock and his colleagues1 of an antirachitic substance in irradiated sterols, Malmström, Villaret, Justin-Besançon and Fauvert, Bergmann2 and others discovered that these new forms of vitamin D were useful in the treatment of various types of tuberculosis.

In 1930 Levaditi and Po and Spies3 reported that experimental tuberculosis in rabbits was distinctly benefited by the administration of large doses of irradiated ergosterol. These investigators observed that tuberculous tissue had a selective tendency to become calcified under the influence of this substance. A mineral shell formed around the areas of necrosis, and within this shell the tubercle

Add or change institution
×