SINCE penicillin, in the process of its present day manufacture, takes substances from two sources, namely, the fungus Penicillium and the culture medium, which are known to be potential antigens, it would be reasonable to predict that penicillin would be capable of producing the same types of allergic reactions as would these parent substances. This prediction has come true in the experience of users of penicillin. It will be the purpose of this paper to correlate and to describe the various types of cutaneous reactions which have occurred in our practice and that of our colleagues.
As penicillin in the strengths usually applied to the skin in solutions or in ointments is not a primary cutaneous irritant, it should not, in theory, produce contact dermatitis when applied to skin which has not been sensitized by previous application of penicillin or by some other fungus.Cohen and Pfaff1
TEMPLETON HJ, LUNSFORD CJ, ALLINGTON HV. CUTANEOUS REACTIONS TO PENICILLIN. Arch Derm Syphilol. 1947;56(3):325–338. doi:10.1001/archderm.1947.01520090045005
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