A GENERAL report on the use of theophylline ethylenediamine (aminophylline) by injection as an antipruritic agent was presented in a previous paper.1 It was demonstrated that this agent was most effective when administered intravenously. However, when the drug was given by this route, disconcerting immediate reactions, and even possible fatal reactions, limited its value in dermatology. The evanescence of the relief also indicated that further studies were necessary to make its use practical. The present report concerns the results obtained in 17 patients suffering with various itching dermatoses who were treated with intramuscular injections of aminophylline.
Seventeen patients were studied. The table briefly outlines the salient features in each instance. Thirteen patients were women, and 4 were men. All but 2 were white, and the others were Negro. The ages ranged from 31 to 71 years, roughly two thirds being between the ages of 41 and 60 years.
EPSTEIN E. AMINOPHYLLINE AS AN ANTIPRURITIC AGENT: II. Intramuscular Injection. Arch Derm Syphilol. 1947;56(3):373–375. doi:10.1001/archderm.1947.01520090093011
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