MYCOSIS fungoides has always been a subject for debate. Many investigators consider it neither a clinical nor a histologic entity. Therefore, they have placed it in the inclusive group of lymphoblastomas. Further support for this is the fact that mycosis fungoides may simulate other diseases of this group.
The histologic structure in the clinical picture of mycosis fungoides may be granulomatous, reticuloendotheliomatous or reticulosarcomatous. The reticulum of the skin is considered by many to be the site of origin. Some have thought that the perithelium, endothelium, adventitial or periadventitial histiocytes of the blood vessels in the cutis or the fixed connective tissue cells and fibroblasts were the matrix. The widespread character of the reticulum accounts for the generalized reaction, which is a constant feature of the disease.
The variable histologic appearance of mycosis fungoides is based on the many potentialities of differentiation of the reticulum cell. Scott and Robb-Smith,1
WINER LH. MYCOSIS FUNGOIDES: Benign and Malignant Reticulum Cell Dysplasia. Arch Derm Syphilol. 1947;56(4):480–498. doi:https://doi.org/10.1001/archderm.1947.01520100076012
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