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Article
October 1947

DEVELOPMENT OF SQUAMOUS CELL EPITHELIOMA IN EPIDERMOLYSIS BULLOSA: Report of a Case

Arch Derm Syphilol. 1947;56(4):517-522. doi:10.1001/archderm.1947.01520100113016
Abstract

EPITHELIOMA has been known to occur in the lesions of such chronic cutaneous diseases as psoriasis, eczema, hypertrophic lichen planus and blastomycosis. The resulting tumor may be either basal or squamous cell epithelioma.

It is also well known that epithelioma may develop in scar tissue resulting from such causes as burns of varied origin, trauma, syphilis, tuberculosis, lupus vulgaris and lupus erythematosus. When scar tissue undergoes carcinomatous change it is generally of the squamous cell type. Obviously then, there is nothing startling in reporting the development of carcinomatous change in a lesion of chronic dermatosis or in cicatricial tissue. However, the case to be reported would appear to be of interest for two reasons. First, a search of the literature did not disclose a report of the occurrence of epithelioma as a sequel of epidermolysis bullosa, and, second, the development of bilateral squamous cell epithelioma of the lower extremities is

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