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Article
November 1947

PROPIONATE-CAPRYLATE MIXTURES IN THE TREATMENT OF DERMATOMYCOSES: With a Review of Fatty Acid Therapy in General

Arch Derm Syphilol. 1947;56(5):601-613. doi:10.1001/archderm.1947.01520110047007
Abstract

THE USE of the fatty acids in the treatment of mycotic infections was introduced by Peck and his associates.1 They were led to this treatment because their investigations had convinced them that human perspiration played a role as a protective mantle against infections generally and fungous infections in particular. The basis for their treatment was founded on the fact that they were able to demonstrate that sweat was fungicidal and fungistatic, because of its content of fatty acids. Previous investigations on the fatty acid series from C1 to C11 by Peck and Rosenfeld2 had demonstrated that the fatty acids inhibited growth of pathogenic fungi and that in proper concentration many of them were fungicidal. Since then many investigators have confirmed the therapeutic value of fatty acids in mycotic diseases.

It is important to emphasize that the use of fatty acids is an advance in treatment, not

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