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December 1947

HISTOPLASMOSIS: Cutaneous and Mucomembranous Lesions, Mycologic and Pathologic Observations

Author Affiliations


From the Departments of Dermatology, Bacteriology and Pathology, University of California Medical School.

Arch Derm Syphilol. 1947;56(6):715-739. doi:10.1001/archderm.1947.01520120003001

HISTOPLASMOSIS should be of interest to dermatologists because cutaneous or mucomembranous lesions have been observed in one half of the reported cases. The literature has been reviewed, disclosing reports on 88 patients with the disease. In 1945, Parsons and Zarafonetis1 referred to 71 of these cases. We have read of 17 more2 and have added 1 of our own. Cutaneous or mucomembranous lesions were observed in 45 (50 per cent) of the 88 patients.3 We believe that these facts warrant a review of the subject.

HISTORICAL REVIEW  Darling observed the first cases of histoplasmosis in Panama in 1906,3h 19083i and 19094 while searching for examples of visceral and cutaneous leishmaniasis. Strong2a saw a patient in the Philippine Islands at about the same time with an abscess which may have been due to the same or to a similar organism. Darling named the

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