MANY reports in the literature emphasize the frequent occurrence of cutaneous sensitivity following the topical application of the sulfonamide group of drugs. Darke1 treated 218 patients with injuries of a minor surgical nature with a 5 per cent sulfathiazole cream and observed 12 instances in which sensitivity developed (5.5 per cent). Inges2 treated 300 patients with sulfathiazole and sulfadiazine in salves, powders and lotions. Sensitivity reactions were observed in 10 patients (3.3 per cent). Robert3 observed 4 cases of hypersensitivity to sulfathiazole ointment when making patch tests on 200 patients who had never been treated with sulfathiazole. Cole,4 in the report for the Council on Pharmacy and Chemistry of the American Medical Association, reviewed the literature on the local use of the sulfonamide compounds in dermatology. He advised that sulfonamide drugs should not be applied locally for more than five days because of the danger of
GOTTSCHALK HR, WEISS RS. STUDIES ON SENSITIVITY TO SULFONAMIDE OINTMENTS. Arch Derm Syphilol. 1947;56(6):775–779. doi:https://doi.org/10.1001/archderm.1947.01520120063006
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