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December 1947

KAPOSI'S VARICELLIFORM ERUPTION: Isolation of the Virus of Herpes Simplex from the Cutaneous Lesions of Three Adults and One Infant

Author Affiliations


From the Children's Hospital Research Foundation and the Departments of Pediatrics, Bacteriology and Dermatology and Syphilology of the University of Cincinnati College of Medicine.

Arch Derm Syphilol. 1947;56(6):846-863. doi:10.1001/archderm.1947.01520120134015

TOWARD the end of the last century Kaposi1 described a syndrome in children. The young patients experienced an eruption and a febrile reaction as a complication of preexisting atopic dermatitis. Lesions usually appeared over the old atopic dermatitis, but occasionally invaded the neighboring healthy skin. The lesions went through various stages of vesiculation, umbilication, desiccation and rupture. The acute lesions appeared in recurrent crops for many days, and when they finally healed only signs of the original atopic dermatitis persisted. No mention was made in the original description of lymph node involvement, which was a common observation in subsequent reports of similiar cases. Shortly thereafter, under the title of "Pustulosis acuta varioliformis," Juliusberg2 described a fatal case in which there were lesions similar to those of Kaposi's varicelliform eruption. A similar disease picture has been described by many authors under the name of eczema vaccinatum. Many of these