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Article
January 1948

DERMATITIS FOLLOWING THE USE OF NITROFURAZONE

Author Affiliations

Assistant Physician and Assistant in Dermatology, Massachusetts General Hospital; Graduate Assistant in Dermatology, Massachusetts General Hospital BOSTON

Arch Derm Syphilol. 1948;57(1):124-128. doi:10.1001/archderm.1948.01520130127012
Abstract

A new group of bacteriostatic agents, the nitrofurans, of which 5-nitro-2-furaldehyde semicarbazone1 is an example, has been found effective in the treatment of infected wounds.2 To our knowledge, no examples of cutaneous sensitization to this particular group of drugs have been reported.

Recently, we have had the opportunity of studying a patient in whom dermatitis developed following the application of an ointment containing 5-nitro-2-furaldehyde semicarbazone to an ulcer of the leg.

REPORT OF A CASE  L. B., a white man aged 40, consulted one of us (W. R. H.) on Feb. 6, 1946, for treatment of a mild acneform eruption. The eruption consisted of numerous small papulopustular lesions on the shoulders. Routine treatment with sulfur lotions and ultraviolet radiation was instituted in an attempt to heal these lesions prior to surgical treatment of a recurrent dislocation of the right humerus.On April 3, at which time the acneform

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