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March 1948

LICHEN SCROFULOSUS: Its Development During Treatment with Calciferol for Lupus Vulgaris

Arch Derm Syphilol. 1948;57(3_PART_I):392-395. doi:10.1001/archderm.1948.01520150114015

Successful treatment for lupus vulgaris with large doses of calciferol (vitamin D2) was first reported by Charpy of France in 1943.1 This investigator, speculating that the increase of lupus vulgaris in France during 1941 was related to nutritional deficiencies and recognizing the favorable response of lupus to cod liver oil and heliotherapy, concluded that large doses of vitamin D might be beneficial in this condition. Calciferol in propylene glycol was administered by mouth to a series of 27 patients. The schedule of treatment was 15 mg., or 600,000 international units, of calciferol once weekly for three months followed by the same dose every two weeks for the next three months. In addition, a high calcium intake was prescribed, either in the form of 1 to 2 liters of milk or 0.5 Gm. of calcium gluconate daily. All 27 patients were considered clinically cured at the end of three

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