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March 1948


Arch Derm Syphilol. 1948;57(3_PART_II):581-589. doi:10.1001/archderm.1948.01520160179008

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Granuloma Inguinale. Presented by Dr. S. E. Sweitzer.  W. H., a Chinese man aged 61, first noted an eruption in the groin seven years ago. After about three years the lesions spontaneously disappeared. About two years ago new lesions appeared in the same area and, despite treatment, persisted to the time of admission to Minneapolis General Hospital.Reactions in serologic tests for syphilis were negative. Smears from the ulcers showed many bacilli, but no Donovan bodies were seen. Cultures were unsatisfactory because of the overgrowth of Escherichia coli. Histologic sections showed intracellular bodies which were considered to be Donovan bodies. On Dec. 12, 1945, the patient was given 1 cc. of a 5 per cent solution of "fuadin" N. N. R., and the dose was increased 0.5 cc. each day until the maximum dose of 5 cc. was attained. The patient was given 5 cc. each day until his death.

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