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Article
April 1948

NODULOULCERATIVE GRANULOMA OF THE LEGS: Treatment with Tocopherols

Author Affiliations

MONTREAL, CANADA

From the Departments of Dermatology and Pathology, Montreal General Hospital.

Arch Derm Syphilol. 1948;57(4):605-614. doi:10.1001/archderm.1948.01520170003001
Abstract

A CASE of granuloma of the legs, with lipoidal changes compatible with a diagnosis of necrobiosis lipoidica diabeticorum, is reported because of the rapid response to treatment with preparations of vitamin E, together with histologic studies of changes in the course of treatment.

REPORT OF A CASE  Mrs. C., aged 52, in whom diabetes was first discovered in 1941, appeared in the clinic in 1942, with nodular lesions in both legs, at which time a diagnosis of erythema induratum, of the Phillipson type, was made. Rest and supportive treatment resulted in partial cure, with, however, a relapse in 1943, when ulceration occurred on the anterior aspect of the left shin. Exacerbations occurred from this time on, with involvement of both legs. She was obese.In September 1946, there were multiple ulcerative lesions on the lower third of both shins, associated with pain and tenderness. No deep nodose lesions were felt,

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