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April 1948

SARCOIDOSIS: Report of an Atypical Case with Erythrodermic Lesions, Subcutaneous Nodes and Asteroid Inclusion Bodies in Giant Cells

Author Affiliations


From the Departments of Dermatology and Pathology, Massachusetts General Hospital.

Arch Derm Syphilol. 1948;57(4):639-654. doi:10.1001/archderm.1948.01520170037005

A CASE of sarcoidosis with several unusual features recently came under observation. The patient presented erythrodermic lesions, a rare manifestation of sarcoidosis, together with subcutaneous nodes consistent with those described as Darier-Roussy's sarcoid. In addition, histologic examination of the nodes revealed asteroid inclusion bodies in giant cells.

REPORT OF A CASE1  A 45 year old caretaker first noticed, in the fall of 1942, red slightly scaling patches on the inner aspects of the thighs, in the groins and on the lower part of the abdomen. A few months later similar patches appeared in the right axilla and the right popliteal space. The lesions, which were asymptomatic, slowly increased in size. Early in 1944 the patient noticed additional red patches in the left axilla, on both ankles and on the dorsal aspects of the feet. In March 1944 nontender firm subcutaneous nodes began to appear on the thighs, in the

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