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May 1948

AMBULATORY TREATMENT OF EARLY SYPHILIS: An Experimental Study with Report of Injection of Penicillin in Water-in-Oil Emulsion

Author Affiliations


From the Division of Venereal Disease Research (Dr. Cohn and Dr. Grunstein) and the Bureau of Social Hygiene (Dr. Rosenthal), Department of Health, New York.

Arch Derm Syphilol. 1948;57(5):900-906. doi:10.1001/archderm.1948.01520180117012

THIS report deals with various instructive observations recorded in the course of an experimental study of ambulatory treatment of patients with early syphilis with penicillin in water-in-oil emulsion. The commercial production of the original oily vehicle designed for retarding absorption and excretion and used in this investigation1 has already been replaced by some others, which, however, also employ the same fundamental principles first reported by Freund and Thomson.2 Nevertheless, it is hoped that the therapeutic response observed with this type of treatment will promote further research in this direction and also stimulate the investigation of other problems encountered in this study. Our results, therefore, are not intended to present a schedule for routine treatment. What follows is merely a pilot study, which may be used as a guide to a further approach to this problem.

METHOD OF TREATMENT  The use of a single intramuscular injection of sodium penicillin

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