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June 1948

TOCOPHEROLS (VITAMIN E): Treatment of Lupus Erythematosus; Preliminary Report

Author Affiliations


From the Dermatological and Pathological Departments of the Montreal General Hospital.

Arch Derm Syphilol. 1948;57(6):953-964. doi:10.1001/archderm.1948.01520190032005

WITH THE knowledge that the administration of tocopherols (vitamin E) had, in sufficient dosage, demonstrated a profound ability to regenerate collagenous tissue in a case of noduloulcerative granuloma with lipoidal deposits, indistinguishable from necrobiosis lipoidica diabeticorum,1 it was logical that certain other entities which have been grouped by Klemperer and his co-workers2 as diseases affecting primarily collagenous ground substance, irrespective of causation, should be investigated and treated in similar manner.

Thus, a series of cases of lupus erythematosus were studied with a view to determining the value of mixed tocopherol therapy in this disease. Any investigative observations as to foci of infection, or other aspects not exactly pertinent to this study, are omitted.


Case 1.—  Mrs. C. R. A., aged 24, presented raised somewhat thickened patchy lesions of lupus erythematosus about the eyes, cheeks and sides of the neck, of about three years' duration. This

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