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June 1948

SITES OF DEPOSITION OF SILVER IN ARGYRIAWith Special Reference to the Axillary Glands

Author Affiliations


From the Departments of Dermatology and Syphilology and Anatomy, University of Michigan Medical School, Ann Arbor.

Arch Derm Syphilol. 1948;57(6):1009-1012. doi:10.1001/archderm.1948.01520190088011

BECAUSE of its accompanying cutaneous discoloration, argyria has dermatologic significance. Consequently, some attention has been given to the distribution of silver deposits in the skin of patients with argyria, but, in general, these studies have not included the large specialized sweat glands seen in the axillary and circumanal regions, which are usually regarded as being apocrine in secretory type. It has been noted that silver tends to be deposited in the subepidermal connective tissues, the connective tissue covering the sebaceous and small sweat glands, the perimysium, perineurium, the walls of blood vessels and the arrectores pilorum muscle.1 The importance of the small sweat glands in this disease may be indicated by the suggestion of Firth and Harrison1c that silver is deposited first in the connective tissue surrounding them before it appears in some of the other locations. Only Riemer2 studied the large axillary sweat glands in a

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