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Article
July 1948

TREATMENT OF FAMILIAL BENIGN CHRONIC PEMPHIGUS: Rapid Improvement with Penicillin Therapy

Arch Derm Syphilol. 1948;58(1):80-83. doi:10.1001/archderm.1948.01520200083011
Abstract

The reports that have been published concerning the treatment of familial benign chronic pemphigus are, for the most part, discouraging.

Because of the repeated observation of the staphylococcus1 and the occasional presence of short-chained streptococcus1b in the vesicles, bullae and crusts characteristic of this affliction, the use of local antiseptics has been the most popular therapeutic approach. Beneficial effects have been noted from the local applications of ammoniated mercury ointment in 1 per cent to 3 per cent concentration,2 boric acid ointment2b and mildly antiseptic wet dressings, including alibour water (water containing zinc and copper sulfates.)2 Superficial roentgen therapy has been successful in some patients,3 but in others has proved ineffective.4 Ultraviolet irradiation produced no improvement in a patient treated by Lynch.1d

In an endeavor to achive more permanent results, many types of internal therapy have been tried. The intravenous injections of

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