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Article
October 1948

GENETICS OF XANTHOMA TUBEROSUM MULTIPLEX

Author Affiliations

LOUISVILLE, KY.; ANN ARBOR, MICH.; SAGINAW, MICH.

From the Departments of Dermatology and Syphilology and Internal Medicine, University of Michigan Medical School, and the Heredity Clinic of the Laboratory of Vertebrate Biology, University of Michigan.

Arch Derm Syphilol. 1948;58(4):409-429. doi:10.1001/archderm.1948.01520230054008
Abstract

THE PRIMARY essential xanthomatoses have been divided by Thannhauser and Magendantz,1 Montgomery2 and others on the basis of the clinical picture and the fat content of the blood. The xanthoma tuberosum type with which this paper will concern itself is characterized by hypercholesteremia and a tendency to xanthomatous involvement of the skin, tendon tumors and, of much graver consequence, early cardiovascular disease.

Although the familial occurrence of this condition has been recognized by many observers3 since its description in 1851 by Addison and Gull, Török3d was apparently the first to emphasize the hereditary nature of the disease. In the intervening years there have been several excellent reviews and reports touching on the genetic problems involved. The conclusions drawn have been of a conflicting nature, and the authors may be divided into several groups: (a) those4 who stated the belief that the mode of inheritance of

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