EARLY in 1945, various iron salts were being screened in patients with acne. The purpose was to study the effects of either the cation or the anions. An iron deficiency is common among adolescent girls. M. B. was a white married woman, aged 22, with pustular acne of six years' duration. In addition to routine therapy, she received ferrous iodide. An excellent clinical result attended the supplement. A sister, D. C., aged 19, presented a similar eruption, of four years' duration. Identical treatment was instituted with the exception that ferrous sulfide was prescribed. Her result was poor. Other patients with acne had received ferrous sulfide with indifferent effects. The subsequent course of the acne in these sisters made us consider that iodine may have influenced their response to treatment.
Cautiously iodine was prescribed for other patients. Two patients (cases 38 and 41) received an average of 56 mg. weekly (table).
GAUL LE, UNDERWOOD GB. ORAL IODINE THERAPY IN ACNE VULGARIS: Failure of Iodine, or the Equivalent of Iodized Salt, to Produce Pustular Exacerbations. Arch Derm Syphilol. 1948;58(4):439–443. doi:10.1001/archderm.1948.01520230084010
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