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January 1949

SENSITIVITY TO TUBERCULIN OF PERSONS WITH ACNE: The Importance of Age in Its Interpretation; a Study of 1,136 Students

Author Affiliations

Professor of Bacteriology and Public Health, Tufts College Medical and Dental Schools BOSTON

Student Fellow, Department of Pathology and Bacteriology, Tufts College Medical and Dental Schools.

Arch Derm Syphilol. 1949;59(1):11-15. doi:10.1001/archderm.1949.01520260015002

THE RELATION between acne vulgaris and tuberculin sensitivity has received sporadic attention in the medical literature for the past fifteen years. In a review of the literature up to 1943, Loewenthal1 cited the work of German investigators of the early nineteen thirties as first indicating the problem. He speaks of the observation by Ramel in 1928 of acid-fast bacilli in the closed lesions of 4 patients with acne vulgaris and of the same worker's discovery of ten more such cases in 1930. In each case the laboratory observation was verified by guinea pig inoculation but none of these patients had clinical tuberculosis. He stated also that Griesbach in 1930 reported acne in no less than 30 per cent of 18,000 cases of active tuberculosis.

In 1934, von Kemeri2 reported a series of 52 patients with acne, all of whom presented roentgenographic evidence of tuberculosis of moderate severity, positive

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