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March 1949


Arch Derm Syphilol. 1949;59(3):263-276. doi:10.1001/archderm.1949.01520280015002

Although highly malignant, anaplastic epithelioma has received little attention from members of the medical profession and references to it in the literature are rather meager. Paget's tumor, Bowen's tumor (precancerous dermatosis) and nevocarcinoma (malignant melanoma) have been discussed in detail, but only as individual types of carcinoma, and not as parts of a general process. It is the purpose of this communication to present an organized description and classification of anaplastic epithelioma which we believe is distinct from epithelioma of the basal cell, spinobasal cell and prickle cell types.

CLASSIFICATION AND PATHOGENESIS  The cells in this type of malignant neoplasm are described as anaplastic, embryonic or undifferentiated. These terms are used interchangeably and characterize the cells only in part. A composite name embodying the features of all three would be preferable, since no one of these terms is entirely satisfactory. Epitheliomas characterized by this type of cell may be either

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