SOON AFTER penicillin was found to be effective in the treatment of early syphilis,1 the Penicillin Panel of the Subcommittee on Venereal Diseases, National Research Council, assigned to the department of dermatology and syphilology at the University Hospitals and the Cleveland City Hospital the treatment of early infectious syphilis with three schedules, utilizing small amounts of penicillin (1,000 and 1,500 units) alone or in combination with oxophenarsine ( mapharsenR ). Between November 1943 and June 1944, 159 patients with syphilis exhibiting dark field—positive primary or secondary lesions were treated by one of these three schedules. An immediate favorable effect on disappearance of the mucocutaneous lesions and reversal of the serologic titer was noted; however, after a few months' observation the rate of relapse was so high that these schedules were abandoned. A report on the observation of these patients was make by Binkley and Kile2 in March 1945, after
WALKER AE, UTTERBACK M, Ayres S, et al. TREATMENT OF EARLY SYPHILIS WITH SMALL DOSES OF CRUDE PENICILLIN. Arch Derm Syphilol. 1949;59(3):277–283. doi:10.1001/archderm.1949.01520280029003
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