The history and microscopic appearance of tissue in the case described here were sufficiently typical to justify a diagnosis of granuloma pyogenicum, but the clinical appearance, especially the enormous size of the lesion, was so bizarre as to confuse the diagnosis.
Granuloma pyogenicum was first described under this name by Crocker1 in 1903, although it had previously been reported by Poncet and Dor2 in 1897 under the name botryomycose humaine. The first cases reported in the United States were described by Hartzell3 in 1903. Since that time the disease has become a well established entity, familiar to all dermatologists.
Trauma is a common precipitating factor. The lesion may be present on any part of the cutaneous surface and in its common form occurs singly. It is usually pedunculated or sessile, is highly vascular, bleeds easily, with a moist or crusted surface, and attains the average the size
AYRES S. GRANULOMA PYOGENICUM GIGANTEUM. Arch Derm Syphilol. 1949;59(3):333–338. doi:10.1001/archderm.1949.01520280085009
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