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March 1949


Arch Derm Syphilol. 1949;59(3):339. doi:10.1001/archderm.1949.01520280091011

Jansen1 first developed carboxymethylcellulose in Germany in 1918 as a substitute for gelatin, glue, agar-agar, tragacanth and similar substances. Carboxymethylcellulose is used chiefly in industry in the form of its sodium salt. Sodium carboxymethylcellulose is indicated whenever hydrophilic colloids having suspending, stabilizing, film-forming and thickening properties are needed.

Brown and Houghton2 stated that sodium carboxymethylcellulose can be used as an emulsifying agent and whenever a protective colloid is required in oil in water emulsions. According to these authors, it is nontoxic.

About a year ago I became interested in the possibility of using carboxymethylcellulose in dermatology, particularly in lotions when oil in water emulsions are needed. After many trials, I compounded a lotion consisting of the following formula in aqueous solution: sodium carboxymethylcellulose, 0.75 per cent; non-aethylene glycol monolaurate, 1 per cent, and triethanolamine, 1 per cent.1a In this formula the carboxymethylcellulose acts as a film-forming agent

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