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May 1949

FACTORS IN AMORPHOUS PENICILLIN G INFLUENCING GROWTH OF FUNGI: I. Effect on Elaboration of Trichophytin by Trichophyton Gypseum

Author Affiliations


From the Dermatologic Service of Mount Sinai Hospital.

Arch Derm Syphilol. 1949;59(5):498-505. doi:10.1001/archderm.1949.01520300008002

THERE are a number of in vitro methods for evaluating the fungicidal and fungistatic activity of therapeutic agents.1 However, the clinician is often confronted with discrepancies between the laboratory data and the clinical effectiveness. This situation is due in part to the fact that in the testing of fungicides in vitro there is not considered the special circumstance which is present in most fungous diseases. This specific condition is due to the allergy to the fungus, which is the chief component in the clinical manifestations. It certainly exists in dermatophytosis of the feet, the fungous disease most commonly treated.

In our laboratory we have developed a method for the evaluation of fungicides which takes into consideration not only the fungicidal activity of a therapeutic agent but also the effect of the agent on the metabolism of the organisms. The metabolites with which we were chiefly concerned were those which

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