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Article
May 1949

NODULAR SUBEPIDERMAL FIBROSIS (DERMATOFIBROMA VERSUS HISTIOCYTOMA)

Author Affiliations

EDMONTON, ALBERTA, CANADA; ROCHESTER, MINN.

From the Section on Dermatology and Syphilology, Mayo Clinic.

Arch Derm Syphilol. 1949;59(5):568-583. doi:10.1001/archderm.1949.01520300078011
Abstract

THIS article is based on clinical and pathologic studies of 95 patients who had 1 or more lesions of nodular subepidermal fibrosis.

Unna,1 in 1896, first described the condition as "fibroma simplex." It has become widely known as "dermatofibroma lenticulare"2 or as "nodular subepidermal fibrosis."3 For many years a fibroblastic, and possibly traumatic, origin of the condition was accepted. However, in articles published from 1931 to 1933, Woringer and his associates4 questioned the fibroblastic origin of all these lesions and described what Woringer believed formed a separate entity under the title "histiocytoma." He and his associates found phagocytic reticuloendothelial cells. Their observations were supported by the studies of Senear and Caro5 with the use of vital stains. More recently, in 1943, Gross and Wolbach6 described a series of cases similar to those described by Woringer and his associates but advanced the belief that the

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