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August 1949

TREATMENT OF EARLY SYPHILIS WITH PENICILLIN: Report on Three Hundred and Twenty-Four Patients Treated with 1,200,000 Units Over Seven and One-Half Days

Author Affiliations

DUBUQUE, IOWA; Senior Surgeon, United States Public Health Service WASHINGTON, D. C.; DAYTON, OHIO; CINCINNATI

From the Chicago Intensive Treatment Center, Venereal Disease Control Program, Chicago Board of Health, in cooperation with the United States Public Health Service.

Arch Derm Syphilol. 1949;60(2):150-154. doi:10.1001/archderm.1949.01530020018004

THE PUBLICATION of a report by Mahoney, Arnold and Harris.1 in 1943 on the effectiveness of 1,200,000 units of penicillin given over an eight day period stirred the world of syphilotherapy profoundly. It was not long before other investigators published their results of treatment in early syphilis with similar amounts of the drug. Thus, Binkley and Kile2 reported their observation on 10 patients, who had received 1,200,000 units of penicillin over varying periods of time, 7 of whom were seronegative and clinically well one year after treatment. In a recent article by the Committee on Medical Research of the Office of Scientific Research and Development and the United States Public Health Service3 the results of treatment were given in 1,073 patients with early syphilis; 1,200,000 units of penicillin were used over a seven and one-half day period in intramuscular injections given every three hours. Of these,

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