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August 1949

TREATMENT OF EARLY SYPHILIS WITH PENICILLIN G: Administration of Penicillin G in Peanut Oil and Wax Twice Weekly for Eight Weeks

Arch Derm Syphilol. 1949;60(2):253-260. doi:10.1001/archderm.1949.01530020121015

THE SCHEDULE of treatment discussed in this paper was assigned to Wayne University College of Medicine and the Social Hygiene Clinic of the Detroit Department of Health in March 1946 by the Venereal Disease Committee of the National Research Council, Dr. J. Earle Moore, chairman. Penicillin G in peanut oil and wax (Romansky formula) (600,000 units, 2 cc.) was administered intramuscularly twice weekly for eight weeks. Thus, a total of 9,600,000 units of penicillin was given to the patient in this eight week period. It has been assumed that the most effective results with penicillin in the treatment of syphilis will be secured when a satisfactory level of the drug in the blood is maintained continuously over a given period. The object of this study was to determine whether more widely spaced injections of penicillin continued over a longer period might prove effective in the treatment of a

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