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September 1949


Author Affiliations


From the Department of Dermatology, Columbia University College of Physicians and Surgeons, and the Vanderbilt Clinic, Presbyterian Hospital.

Arch Derm Syphilol. 1949;60(3):377-389. doi:10.1001/archderm.1949.01530030073008

CONSIDERABLE interest has recently been aroused by Kveim's report1 of the production of an unusual cutaneous reaction in patients with sarcoidosis by the intracutaneous injection of heated saline suspensions of tissue obtained from persons with active disease. Kveim found that after the transient inflammatory response caused by the trauma of such an injection had subsided, a small, indurated papule developed at the test site within a variable period of time. This delayed papular reaction was distinctive in that it often required weeks to attain its maximum size and usually remained visible for many months thereafter. Microscopic examination of tissue from sites of such reactions showed a histologic structure essentially the same as that of the lesions of the natural disease. Since control injections of Frei antigen and old tuberculin injected simultaneously with the suspensions of tissue into the same patients produced no comparable response, and, since the sarcoid material

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