In 1941 Engelbreth-Holm1 reviewed 22 cases of leukemia associated with other malignant conditions and added reports of 11 cases of his own. Since then 13 additional cases2 of leukemia combined with various types of malignant diseases have been reported.
Of the 46 cases reported, carcinoma of the skin was associated with the leukemia in 14.3 Basal cell carcinoma was reported in 8 and squamous cell carcinoma in 6 of the cases. Chronic lymphatic leukemia was noted in each of the 14 cases.
We have observed a patient who exhibited multiple squamous cell carcinoma of the skin associated with chronic lymphatic leukemia. We report this case because of apparent rarity of the combined malignant conditions and also because this patient received urethane therapy and showed clinical and hematologic response, as well as definite changes in a squamous cell carcinoma of the skin, which occurrences may be attributed to