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November 1949


Author Affiliations


Arch Derm Syphilol. 1949;60(5_PART_I):781-789. doi:10.1001/archderm.1949.01530050143013

In 1892 Wernicke1 and Posada2 reported the first known case of coccidioidal granuloma. Two years later Rixford3 described the first case in the American literature. At that time the causative agent was considered to be a protozoan; because of the resemblance of the indolent ulcers of the skin in this disease to those produced in animals by coccidia, the name of coccidioides was suggested for this agent. In 1900 Ophuls4 recognized and described the causative agent as a moldlike parasite which was readily cultured on various mediums. It has been within the last decade that valley fever, the syndrome of influenza and erythema nodosum, has been attributed to coccidioides.5 This recognition of the primary infection has caused a considerable change in attitude toward the disease. Coccidioidal infection, once considered a rarity when recognized only in the granulomatous stage, is now not uncommon; however, the extensive

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