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December 1949


Author Affiliations

President; Secretary Feb. 11, 1947

Arch Derm Syphilol. 1949;60(6):1215-1224. doi:10.1001/archderm.1949.01530070155020

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Mycosis Fungoides (with Vertebral Involvement, Treated with Nitrogen Mustard). Presented by Dr. Ben A. Newman.

R. G., a white woman aged 59, has had a recurrent generalized eczematoid dermatitis for the past eleven years. This condition has been treated with several courses of roentgen radiation. In 1945 a diagnosis of mycosis fungoides was made from a biopsy specimen. During one and one-half years she received roentgen therapy, a course of diphtheria toxoid and injections of antireticular cytotoxic serum without benefit. She was admitted to the hospital again on Nov. 1, 1946. At that time, she presented a generalized dermatitis involving the entire cutaneous surface, consisting of eczematoid infiltration and plaques.

The patient was given two courses of nitrogen mustard (three injections of 6 mg. each) during a two week period. One week after the first injection, involution of the lesions occurred and also pruritus. At the end of three weeks

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